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In my interview with world glutathione expert Dr Jimmy Gutman I accidentally asked a question. that had deeper implications than I realised.

I asked "If we call the outcome of low Vitamin D is Rickets, and the outcome of low vitamin C is called Scurvy, what do we call the outcome of low Glutathione?"

These are excerpts from a recent paper (Sept 28th 2022) nailing the connection between illness and low glutathione.

Low glutathione levels are associated with these 90 + diseases or conditions.

  1. Acetaminophen poisoning / toxicity

  2. ADD

  3. Addison's Disease

  4. Aging

  5. AIDS

  6. Alopecia Areata

  7. ALS

  8. Alzheimer's Disease

  9. Anemia (hemolytic)

  10. Ankylosing Spondylitis

  11. Arteriosclerosis (hardening of the arteries)

  12. Arthritis (rheumatoid)

  13. Asthma

  14. Autism (ASD)

  15. Autoimmune disease

  16. Behcet’s Disease

  17. Blepharitis

  18. Buerger's Disease

  19. Burns

  20. Cachexia

  21. Cancers

  22. Candida infection

  23. cardiomyopathy (idiopathic)

  24. cardiovascular disease

  25. Chronic Fatigue Syndrome

  26. Colitis

  27. COPD

  28. Coronary artery disease

  29. Cystic fibrosis

  30. Diabetes

  31. Crohn’s disease

  32. Eczema

  33. Emphysema

  34. Epstein Barr Viral Syndrome (EBV)

  35. Fibromyalgia

  36. Free Radical Overload

  37. Goodpasture Syndrome

  38. Graves' Disease

  39. Heavy Metal Toxicity

  40. Hepatic dysfunction (liver disease)

  41. Hepatitis B

  42. Hepatitis C

  43. Some day to be added to the list...

  44. Hepatitis D

  45. Hepatitis E

  46. Hepatitis G

  47. Hepatitis I

  48. Hepatitis TT

  49. Hepatitis SMA1

  50. Hypercholesterolemia (high blood cholesterol)

  51. Herpes

  52. HIV Aid's

  53. Huntington's Disease/ Huntington's Chorea

  54. Infections (bacterial, viral, fungal)

  55. Inflammatory bowel disease (IBD)

  56. Influenza

  57. Liver Disease

  58. Lyme Disease

  59. Lupus

  60. Macular Degeneration (diabetic macular degeneration)

  61. Malnutrition

  62. Meniere’s Disease

  63. Methylmercury poisioning

  64. Multiple sclerosis (MS)

  65. Myasthenia Gravis

  66. Neurogenerative diseases

  67. Noise Induced Hearing Loss

  68. Nutritional Disorders

  69. Obsessive Compulsive Disorder

  70. Parkinson's disease

  71. Pemphigus Vulgaris

  72. Polycystic kidney disease

  73. Polycystic ovary syndrome

  74. Primary Billary Cirrhosis

  75. Progeria

  76. Psoriasis

  77. Rheumatic Fever

  78. Sarcoidosis

  79. Scleroderma

  80. Shingles

  81. Stroke

  82. Surgery

  83. Thalassemia

  84. Trichotillomania (Hair Pulling)

  85. Toxic poisoning

  86. Trauma

  87. Unverricht-Lundborg Disease

  88. Vasculitis

  89. Veisalgia (when combined with vitamin C and B1)

  90. Vitiligo

  91. Wegener’s Granulomatosis

There are many more diseases which are not listed above, that are also associated with low glutathione.

To find out more on how to raise glutathione levels naturally, click for more info here.

The Role of Glutathione Metabolism in Chronic Illness Development and Its Potential Use as a Novel Therapeutic Target


Low GSH levels have been associated with many chronic pro-inflammatory conditions, such as metabolic syndrome, cardiovascular, renal, and hepatic disease, as well as neurodegenerative conditions and autoimmune diseases.

Several large prospective studies support this hypothesis by demonstrating that higher GGT levels are correlated with the risk of developing metabolic syndrome and cardiovascular disease in a dose-dependent fashion.

Human and animal trials utilizing GSH augmentation using precursor supplementation in chronic conditions, including metabolic syndrome, cardiovascular disease, hepatic disease, renal disease, and neurodegenerative conditions, were also reviewed.

There is strong evidence that GSH supplementation leads to improved outcomes in all of these chronic conditions.

This review seeks to highlight the role of GSH in chronic disease progression because a simple and cost-effective strategy can be created to screen for, track, and intervene in susceptible patients at the earliest possible time in the disease process.

Such a novel strategy would impact the majority of chronic diseases contributing to the bulk of morbidity and mortality in the Western world, and, thus, even minor benefits across many conditions may substantially impact population-wide health and longevity.

The biochemical role of glutathione as a driver of chronic illness

Low total GSH levels and elevated ratios of oxidized to reduced GSH are common in chronic illnesses as well as advanced age.

While these relationships have been known for years, most literature has overlooked these findings as the predictable result of increased inflammation and oxidative stress similar to other biomarkers such as C-reactive protein (CRP).

Few, if any, studies have explored the possibility of low GSH levels as a potentially important causative driver of disease pathology in itself

​Papers Conclusions

GSH is a key thiol antioxidant in the human body which, among its many functions, serves as a major mitochondrial protector, and through this function is linked to many chronic illnesses which make up the bulk of the healthcare burden in Western societies today.

Studies presented in this review show that low GSH levels have a demonstrable correlation to the faster onset of these chronic diseases and increased mortality.


The study above mentions NAC which is basically manmade cysteine.

Most NAC is made from recycled human hair.

NAC can become toxic, having the reverse effect becoming oxidative.

There is a better way of introducing natural highly bioavailable cysteine - more info here.

References to the paper above

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