GLUTATHIONE
 

The fine art of Detoxification

Glutathione is the mother of antioxidants, known as the master antioxidant.
The body struggles to make use of Glutathione supplements since the body digests glutathione and .
The body needs the Glutathione precursors so that it can make its own Glutathione where and when it needs it. 
Get your free PDF featuring studies on glutathione here.

The three amino acid precursors needed by the body to make Glutathione are:

1  - Glutamate
2 - Glycine
3 - Cysteine

Glutamate is found in all meats, poultry, fish, eggs, unpasteurized dairy products, undenatured whey protein, and protein-rich plants are dietary sources of glutamate.

Glycine is abundant in high protein foods like fish, meat, beans, nuts and dairy products.

Cysteine is present in all high-protein foods: all meats and poultry, dairy and eggs, quinoa, buckwheat.
Small amounts of cysteine can be found in other plant sources: broccoli, Brussels sprouts, red and yellow bell peppers, onions, garlic.​

However, cysteine is easily destroyed by heat, mechanical stress and cooking. 
To absorb it meats, eggs and vegetables need to be eaten raw!

 

DOES PURE GLUTATHIONE WORK?

Straight Glutathione Supplements
Glutathione is quickly destroyed by the digestive system and does not raise your cellular glutathione levels as shown in this study.

Glutathione is also made from GM bacteria.

Don't waste your money on oral glutathione supplements, whether they are reduced or otherwise at the health food store or online.
They simply won't help you to know how to raise glutathione.
They won't work.

NAC



 

SPECIAL WHEY PROTEIN ISOLATE

Undenatured Whey Protein: Also called bioactive whey protein. Undenatured whey protein is a globular protein isolated from whey. The most common form of whey available comes from cow’s milk.

Raw milk contains about 20% whey. Because of pasteurization and the legal requirements regarding this today, all milk being sold commercially now is pasteurized and thus “dead” from a biological standpoint.

So, the milk that you buy in the grocery store does not contain undenatured whey protein and will not help you to learn how to raise glutathione.
 

All whey proteins that you can buy in the store are denatured, which means they are not bioactive. If you can buy it in a tub, and it comes in vanilla, chocolate, and strawberry, it is great as a dietary source of whey, but has been “killed” in this way and will have no effect on how to raise glutathione levels in your cells.

It is not undenatured whey protein, and it is not bioactive, even if the label says it is. It will not help you to know how to raise glutathione.

 

To have a measurable affect on glutathione levels, the protein must be bioactive or undenatured. This will also help to build up your immune system.
 

What this means is the whey must be processed in such a manner that the heat-sensitive proteins and amino acids are preserved. When these amino acids are preserved, you end up with an efficient way to deliver cysteine to the cells. This is an important factor to consider when learning how to raise glutathione in your cells.
 

The form in which it is found in mother’s breast milk and in raw cow’s milk is called bonded cysteine, and is an excellent delivery vehicle for the cell to make glutathione.
 

It has been well known now for many years that babies who are breast fed as infants have very high glutathione levels, and as a result, they have stronger immune systems and resist disease longer as adults. This is because they received lots of bonded cysteine from their mother while breastfeeding!
 

And adults who continue the process by consuming undenatured whey protein also have higher resistance to disease and stronger immune systems. The common factor is bonded cysteine supplementation! This is a key factor in knowing how to raise glutathione in your cells.
 

The proven way to raise glutathione is by this special whey protein isolate containing double-bonded cysteine AND all the other needed amino acids to enable your body to make glutathione where it needs it.
Click here to see the best whey forward >>>

USA PHYSICIANS DESK HANDBOOK

 

SOURCE: https://www.pdr.net/full-prescribing-information/Immunocal-cysteine-257

 

IMMUNOCAL®
Nutraceutical
Glutathione precursor (Bonded cysteine™ supplement)
Powder Sachets

DESCRIPTION and CLINICAL PHARMACOLOGY

IMMUNOCAL® is a specially formulated undenatured whey protein isolate. It holds several patents in the USA and worldwide and is listed by the FDA in the category of GRAS (generally recognized as safe). It assists the body in maintaining optimal concentrations of glutathione (GSH) by supplying the precursors required for intracellular glutathione synthesis. It is clinically proven to raise glutathione values.
 

Glutathione is a tripeptide made intracellularly from its constituent amino acids L-glutamate, L-cysteine and glycine. The sulfhydryl (thiol) group (SH) of cysteine is responsible for the biological activity of glutathione. Provision of this amino acid is the rate-limiting factor in glutathione synthesis by the cells since bioavailable cysteine is relatively rare in foodstuffs.

Immunocal® is a bovine whey protein isolate specially prepared so as to provide a rich source of bioavailable cysteine. Immunocal® can thus be viewed as a cysteine delivery system.

The disulphide bond in cystine is pepsin and trypsin resistant but may be split by heat, low pH or mechanical stress releasing free cysteine. When subject to heat or shearing forces (inherent in most extraction processes), the fragile disulfide bonds within the peptides are broken and the bioavailability of cysteine is greatly diminished.

Glutathione is a tightly regulated intracellular constituent and is limited in its production by negative feedback inhibition of its own synthesis through the enzyme gamma-glutamylcysteine synthetase, thus greatly minimizing any possibility of overdosage.

Glutathione has multiple functions:

  1. It is the major endogenous antioxidant produced by the cells, participating directly in the neutralization of free radicals and reactive oxygen compounds, as well as maintaining exogenous antioxidants such as vitamins C and E in their reduced (active) forms.

  2. Through direct conjugation, it detoxifies many xenobiotics (foreign compounds) and carcinogens, both organic and inorganic.

  3. It is essential for the immune system to exert its full potential, e.g. (1) modulating antigen presentation to lymphocytes, thereby influencing cytokine production and type of response (cellular or humoral) that develops, (2) enhancing proliferation of lymphocytes thereby increasing magnitude of response, (3) enhancing killing activity of cytotoxic T cells and NK cells, and (4) regulating apoptosis, thereby maintaining control of the immune response.

  4. It plays a fundamental role in numerous metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport and enzyme activation. Thus, most systems in the body can be affected by the state of the glutathione system, especially the immune system, the nervous system, the gastrointestinal system and the lungs.

 

INDICATIONS AND USAGE

IMMUNOCAL® is a natural food supplement and as such is limited from stating medical claims per se. Statements have not been evaluated by the FDA. As such, this product is thus not intended to diagnose, cure, prevent or treat any disease.

Glutathione augmentation is a strategy developed to address states of glutathione deficiency, high oxidative stress, immune deficiency, and xenobiotic overload in which glutathione plays a part in the detoxification of the xenobiotic in question.

 

Glutathione deficiency states include, but are not limited to: HIV/AIDS, infectious hepatitis, certain types of cancers, cataracts, Alzheimer's Disease, Parkinsons, chronic obstructive pulmonary disease, asthma, radiation, poisoning by acetominophen and related agents, malnutritive states, arduous physical stress, aging, and has been associated with sub-optimal immune response.

 

Many clinical pathologies are associated with oxidative stress and are elaborated upon in numerous medical references.

Low glutathione is also strongly implicated in wasting and negative nitrogen balance, notably as seen in cancer, AIDS, sepsis, trauma, burns and even athletic overtraining.

Cysteine supplementation can oppose this process and in AIDS, for example, result in improved survival rates.

 

CONTRAINDICATIONS

IMMUNOCAL® is contraindicated in individuals who develop or have known hypersensitivity to specific milk proteins.

 

PRECAUTIONS

Each sachet of IMMUNOCAL® contains nine grams of protein. Patients on a protein-restricted diet need to take this into account when calculating their daily protein load. Although a bovine milk derivative, IMMUNOCAL® contains less than 1% lactose and therefore is generally well tolerated by lactose-intolerant individuals.

 

WARNINGS

Patients undergoing immunosuppressive therapy should discuss the use of this product with their health professional. Individuals with the autosomal-recessive metabolic disorder cystinuria, are at higher risk of developing cysteine nephrolithiasis (1–2% of renal calculi).

 

ADVERSE REACTIONS

Gastrointestinal bloating and cramps if not sufficiently rehydrated. Transient urticarial-like rash in rare individuals undergoing severe detoxification reaction. Rash abates when product intake stopped or reduced.

 

OVERDOSAGE

Overdosing on IMMUNOCAL® has not been reported.

 

DOSAGE AND ADMINISTRATION

For mild to moderate health challenges, 20 grams per day is recommended. Clinical trials in patients with AIDS, COPD, cancer and chronic fatigue syndrome have used 30–40 grams per day without ill effect. IMMUNOCAL® is best administered on an empty stomach or with a light meal. Concomitant intake of another high protein load may adversely affect absorption.

 

RECONSTITUTION

IMMUNOCAL® is a dehydrated powdered protein isolate. It must be appropriately rehydrated before use. Ideally consumed after mixing. If it is premixed for later consumption, it should be refrigerated and consumed shortly after mixing. DO NOT heat or use a hot liquid to rehydrate the product. DO NOT use a high-speed blender for reconstitution. These methods will decrease the activity of the product.

Proper mixing is imperative. Consult instructions included in packaging.

 

HOW SUPPLIED

10 grams of bovine milk protein isolate powder per sachet.

30 sachets per box.

 

STORAGE Store in a cool dry environment. Refrigeration is not necessary.

REFERENCES

REFERENCES

  1. Baruchel S, Viau G, Olivier R. et al. Nutraceutical modulation of glutathione with a humanized native milk serum protein isolate, Immunocal®: application in AIDS and cancer. In: Oxidative Stress in Cancer, AIDS and Neurodegenerative Diseases. Ed.; Montagnier L, Olivier R, Pasquier C. Marcel Dekker Inc. New York, 447–461, 1998

  2. Bounous G, Kongshavn P. Influence of protein type in nutritionally adequate diets on the development of immunity. In Absorption and Utilization of Amino Acids Vol.II. Ed. M. Friedman. CRC Press, Inc., Fla. 2:219–32, 1989

  3. Bounous G, Gold P. The biological activity of undenatured whey proteins: role of glutathione. Clin Invest Med 14:296–309, 1991

  4. Bounous G, Baruchel S, Falutz J. Gold P. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest Med. 16:3; 204–209, 1992

  5. Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res. 20:4785–4792, 2000

  6. Bounous G. Immunoenhancing properties of undenatured milk serum protein isolate in HIV patients. Int. Dairy Fed: Whey: 293–305, 1998

  7. Bray T, Taylor C. Enhancement of tissue glutathione for antioxidant and immune functions in malnutrition. Biochem. Pharmacol. 47:2113–2123, 1994.

  8. Droge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J: 11(13):1077–1089, 1997

  9. Herzenberg LA, De Rosa SC, Dubs JG et al. Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci 94:1967–72, 1997

  10. Kennedy R, Konok G, Bounous G et al.. The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: A phase 1-II clinical study. Anticancer Res. 15:2643–50, 1995

  11. Lands LC, Grey VL, Smountas AA. Effect of supplementation with a cysteine donor on muscular performance. J. Appl. Physiol. 87:1381–1385, 1999

  12. Locigno R, Castronovo V. Reduced glutathione System: Role in cancer development, prevention and treatment. International Journal of Oncology 19:221–236, 2001

  13. Lomaestro B, Malone M. Glutathione in health and disease: pharmacotherapeutic issues. Ann Pharmacother 29: 1263–73, 1995

  14. Lothian B, Grey V, Kimoff RJ, Lands. Treatment of obstructive airway disease with a cysteine donor protein supplement: a case report. Chest 117:914–916, 2000

  15. Meister A. Glutathione. Ann Rev Biochem 52:711–60, 1983

  16. Peterson JD, Herzenberg LA, Vasquez KK, Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc. Natl. Acad. Sci. 95:3071–3076, 1998

  17. Tozer RG, Tai P, Falconer W, Ducruet T, Karabadjian A, Bounous G, Molson J, Dröge W. Cysteine-rich protein reverses weight loss in lung cancer patients receiving chemotherapy or radiotherapy. Antioxidants & redox signalling. 10: 395–402, 2008.

  18. Watanabe A, Higachi K, Yasumura S. et al. Nutritional modulation of glutathione level and cellular immunity in chronic hepatitis B and C. Hepatology. 24:597A, 1996

  19. Witschi A, Reddy S, Stofer B, Lauterberg B. The systemic availability of oral glutathione. Eur. J. Clin. Pharmacol. 43:667–669, 1992.

  20. Grey V, Mohammed SR, Smountas AA, Bahlool R, Lands LC. Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. J Cyst Fibros. 2(4):195-8, Dec 2003.

  21. Baumann JM, Rundell KW, Evans TM, Levine AM. Effects of cysteine donor supplementation on exercise-induced bronchoconstriction. Med Sci Sports Exerc. 37(9):1468-73, Sep 2005.

  22. Chitapanarux T, Tienboon P, Pojchamarnwiputh S, Leelarungrayub D. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients. J Gastroenterol Hepatol. 24(6):1045-50, Jun 2009.

  23. Karelis AD, Messier V, Suppère C, Briand P, Rabasa-Lhoret R. Effect of cysteine-rich whey protein (immunocal®) supplementation in combination with resistance training on muscle strength and lean body mass in non-frail elderly subjects: a randomized, double-blind controlled study. J Nutr Health Aging. 19(5):531-6, May 2015.

 

Manufactured by Immunotec Inc.

Tel: 450-424-9992

Ext. 4453

www.immunocal.com